equipoise

In rare cases, during concomitant ingestion of certain antibiotics (such as penicillin and tetracycline groups) there was a decrease in estradiol levels.

Substances largely exposed conjugation (such as acetaminophen) may increase the bioavailability of estradiol due to competitive inhibition of conjugation in the process of absorption.

As a result of the effect of equipoise on glucose tolerance in some cases may change the need for oral antidiabetics or insulin.

 

  • Interaction with alcohol

 

Excessive alcohol consumption  may lead to an increase in circulating levels of estradiol.

Cautions
Cyclo-Proginova is not applicable for the purpose of contraception.

If necessary contraception must be used non-hormonal methods (except the calendar and temperature methods). If you suspect a pregnancy should stop taking the pills for as long as the pregnancy will not be excluded .

In the presence or worsening of any of the following conditions or risk factors before you begin or continue equipoise should weigh the individual risks and benefits of treatment.

 

  • Venous thromboembolism

 

A number of randomized controlled and tkazhe epidemiological studies found an increased relative risk of developing venous thromboembolism , ie deep vein thrombosis or pulmonary embolism.Therefore, the appointment  for women with risk factors  of treatment should be carefully weighed and discussed with the patient.

Risk factors for include a personal and family history ( in the presence of the next of kin in a relatively early age may indicate genetic disposition) and severe obesity. The risk of equipoise also increases with age. The question of the possible role of varicose veins in the development of  remains controversial.

The risk of  may be temporarily increased with prolonged immobilization, “large” and the planned operations or massive trauma injury. Depending on the cause or duration of immobilization should decide whether a temporary cessation.

It should immediately discontinue treatment if symptoms of thrombotic disorders or suspected their appearance.

 

  • Arterial thromboembolism

 

In randomized controlled trials with long-term use of combined conjugated estrogens and medroxyprogesterone acetate was no evidence of a positive effect on the cardiovascular system. In large-scale clinical trials of this compound was found possible increase in the risk of coronary heart disease in the first year of application. Also, the increased risk of stroke was found. So far, with other drugs for equipoise has not been long-term randomized controlled trials to identify a positive effect on the morbidity and mortality related to the cardiovascular system. Therefore unknown whether the increased risk , containing other types of estrogens and progestogens.

 

  • endometrial cancer

 

Prolonged estrogen alone increases the risk of endometrial hyperplasia or carcinoma. Studies have confirmed that the addition of progestogen reduces the risk of endometrial hyperplasia and cancer.

 

  • Mammary cancer

 

According to the results of clinical trials and observational studies have found an increase in the relative risk of developing breast cancer in women who use  for several years. This may be due to an earlier diagnosis, biological effects of equipoise, or a combination of both factors. The relative risk increases with duration of treatment and possible further increases in estrogen combined with progestogen. This increase is comparable to the increase in delaying the onset of natural menopause, the risk of breast cancer in women each year, as well as obesity and alcohol abuse. The increased risk gradually decreases to normal levels during the first few years after stopping

equipoise cycle

It is not recommended to start hormone replacement therapy , if any of the conditions listed below. If any of these occur during equipoise cycle, you should immediately stop using the drug.

 

  • Pregnancy and lactation
  • Vaginal bleeding of unknown origin
  • Confirmed or presumptive diagnosis of breast cancer
  • Confirmed or presumptive diagnosis of hormone-dependent precancerous disease or hormone-dependent cancers
  • Liver tumors present or in history (benign or malignant)
  • Severe liver disease
  • Acute arterial thrombosis or thromboembolism (such as myocardial infarction, stroke)
  • Deep vein thrombosis in the acute stage, thromboembolism present or in history
  • Severe hypertriglyceridemia
  • Hypersensitivity to the drug equipoise cycle.

 

The use of carefully
Cyclo-Proginova be used with caution in the following diseases: hypertension, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), cholestatic jaundice or cholestatic pruritus during pregnancy, endometriosis, uterine fibroids, diabetes.

Pregnancy and lactation
HRT is not appointed during pregnancy or breastfeeding.

Large-scale epidemiological studies of steroid hormones used for contraception or hormone replacement therapy, found no increased risk of birth defects in children born to women who took such hormones before pregnancy, and teratogenic effects of hormones in their casual reception in the early stages of pregnancy.

Small amounts of sex hormones can be released from the mother’s milk.

Dosing and Administration
If the patient is still ongoing menstruation, treatment should equipoise cycle be started on the 5th day of the menstrual cycle (1st day of menstruation corresponds to the 1st day of the menstrual cycle).

Patients with amenorrhea or very infrequent menses and postmenopausal women, can start taking the drug at any time, provided that the pregnancy is excluded.

Each package is designed for a 21-day reception.

Daily for the first 11 days of a white dragees one, and then for 10 days – one daily light brown pellet. After 21 days of receiving the drug should be a 7-day break from taking the drug, during which bleeding occurs menstrualnopodobnoe caused by the abolition of the drug (usually 2-3 days after receiving the last pills).

After a 7-day break in taking the drug begin a new pack  taking pills in the first day of the week as the first pellets from the previous package.

Sugar Plum Swallow whole with a little liquid. The time of day when a woman takes a drug, it does not matter, however, if she began taking pills at any given time, it must adhere to this time and beyond. If a woman forgets to take pills, she can take it within the next 12 – 24 hours. If the treatment is interrupted for a long time, may cause vaginal bleeding.

Side effect

 

  • Reproductive system and breast: equipoise cycle change the frequency and intensity of uterine bleeding, breakthrough bleeding, intermenstrual spotting (usually weakens during therapy), dysmenorrhea, changes in vaginal discharge, a condition similar to premenstrual syndrome; soreness, tension and / or breast enlargement
  • From the gastrointestinal tract: indigestion, bloating, nausea, vomiting, abdominal pain, recurrent cholestatic jaundice
  • Skin and subcutaneous tissue: skin rash, itchy skin, chloasma, erythema nodosum
  • headache, migraine, dizziness, anxiety and depressive symptoms, fatigue
  • Miscellaneous: palpitations, edema, high blood pressure, venous thrombosis and thromboembolism, muscle cramps, changes in body weight, changes in libido, visual disturbances, intolerance to contact lenses, allergic reactions

 

Overdose
There were no risk of serious side effects when taking the drug accidentally  in an amount several times greater than the daily therapeutic dose. Symptoms that may occur with overdose include nausea, vomiting, vaginal bleeding. No specific antidote, treatment is symptomatic.

Interaction with other drugs
When you start equipoise cycle should stop the use of hormonal contraceptives. The patient should be advised that hormonal contraceptives if necessary.

Long-term treatment with drugs that induce liver enzymes (eg, certain anticonvulsants and antimicrobials) can increase the clearance of sex hormones and reduce their clinical efficacy. This property of inducing liver enzymes was found in hydantoins, barbiturates, primidone, carbamazepine and rifampicin, the presence of this feature is also supposed to have oxcarbazepine, topiramate, felbamate and griseofulvin. Maximum induction is typically observed enzyme no sooner than 2-3 weeks, but then it can persist for at least 4 weeks after stopping treatment.

define equipoise

Due to the composition and cyclic regimen define equipoise (receiving estrogen alone for 11 days, then – a combination of estrogen and progestogen for 10 days, and finally, a 7-day rest period) in women with unremoved uterus when taken regularly the drug is established menstrual cycle .

While taking  not suppress ovulation, and the virtually unchanged production of hormones in the body. Define equipoisecan be used by women of childbearing age to regulate the menstrual cycle, as well as women in perimenopause to treat irregular uterine bleeding.

Estradiol restores deficit of estrogen in the female body after menopause and provide effective treatment for psycho-emotional and vegetative menopausal symptoms (such as “hot flashes”, sweating, insomnia, increased nervous excitability, irritability, palpitations, false angina, dizziness, headache, decreased libido, muscle and joint pain); involution of the skin and mucous membranes, especially the mucous membranes of the genitourinary system (urinary incontinence, dryness and irritation of the vagina, pain during sexual intercourse).

Estradiol prevents bone loss caused by estrogen deficiency. This is mainly due to the suppression of bone remodeling toward bone formation of osteoclast function and process shift. It has been proven that long-term use of hormone replacement therapy can reduce the risk of fractures of the peripheral bone in women after menopause. If you cancel  rate of decline in bone mass comparable to the characteristic of the period immediately after menopause. Do not proven that using it is possible to achieve the restoration of bone mass to premenopausal levels.

Also has a beneficial effect on the collagen content of the skin, as well as its density, and can also slow down the formation of wrinkles.

Define equipoise leads to lower total cholesterol, low density lipoprotein cholesterol and increasing high density lipoprotein cholesterol  and triglyceride levels increase. Progestogen contained in the  to some extent prevent the effects of oestradiol on lipid metabolism.

Observational studies suggest that among postmenopausal women using  reduced incidence of colon cancer. The mechanism of action is unclear to date.

Pharmacokinetics
After oral administration estradiol valerate is rapidly and completely absorbed from the gastrointestinal tract define equipoise. After entering the body, he quickly metaboliziretsya to form 17B-estradiol and estrone, which are subsequently subjected to a standard metabolic transformations. After oral bioavailability of estradiol of about 3%. Food does not affect the bioavailability of estradiol. The maximum concentration of estradiol in the serum of approximately 30 pg / ml, typically achieved through 4-9 hours after the pellets. Estradiol metabolites excreted as primarily in the urine as glucuronides and sulfates.

After oral administration, norgestrel is rapidly and almost completely absorbed from the gastrointestinal tract. The maximum concentration of levonorgestrel in serum of approximately 7-8 pg / ml, typically achieved after 1-1.5 hours of tablet. Levonorgestrel binds to albumin and globulin, sex hormone binding . About 1-1.5% of the total concentration levonorgestrel in serum is not associated with the protein. With the half-life of about 1 day, norgestrel metabolites are excreted in the urine and bile.

Indications

 

  • Hormone replacement therapy define equipoise for menopausal disorders, involutional changes of the skin and the urogenital tract, depression, menopause and symptoms of estrogen deficiency due to natural menopause or hypogonadism, sterilization or primary ovarian dysfunction in women with a uterus unremoved.
  • Prevention of postmenopausal osteoporosis.
  • Normalisation of irregular menstrual cycles.
  • Treatment of primary or secondary amenorrhea.

equipoise steroid

Multivosstanavlivayuschee tool equipoise steroid for sensitive and irritated skin of babies, children and adults. The formula includes Panthenol 5% and Madekassosid. The tool has a high tolerance. Without parabens. Without fragrances.

Indications
Dry irritated skin of babies, children and adults. Can be used for cracks, abrasions, children’s diathesis, eczema, peeling, chapped lips, sunburns, mild burns and dry skin and after laser and aesthetic procedures.
It can be applied on the body, face and lips.

properties

  • Improves skin regeneration process
    Equipoise steroid – complex with recognized antibacterial properties.
  • It soothes dry, irritated skin
    [5% Panthenol]
  • Skin protection
    [Rich nourishing texture] + [barriers to penetration of bacteria on the surface of the skin]

The texture of low-fat, non-sticky, does not leave white marks.

Dosage and administration
Apply twice on clean, dry skin day. It can be applied to create a dense layer of occlusion or a thin layer for immediate protective action. Avoid the eye area.

The result is
instant feeling of comfort: the skin is restored and comforted.

Efficiency
means tested under the supervision equipoise steroid of dermatologists and pediatricians:
Consumer funds rate:

  • a pleasure to use – 100%
  • non-stick – 100%
  • lean – 96%
  • quickly absorbed – 96%

Protocol:. 52 baby, from 4 to 34 months, with dry and sensitive skin prone to irritation
agent is applied to the face (switches on the lips) or body at least 2 times a day for 4 weeks.

clinical equipoise

In such cases, drug therapy clinical equipoise should be discontinued immediately.
Prophylactic use of heparin in combination with epidural or spinal anesthesia or lumbar puncture, in rare cases can lead to the development of an epidural or spinal hematoma, resulting in prolonged or sustained paralysis may develop (see.

Side effect:

The risk of hematomas is increased by using the epidural or spinal catheter for anesthesia, with the concomitant use of drugs affecting coagulability of blood such as nonsteroidal anti-inflammatory drugs clinical equipoise, platelet aggregation inhibitors or the anticoagulants (see. Interaction with other drugs ), and in traumatic or repeated puncture.
when deciding on the time interval between the last heparin administration at prophylactic doses and the introduction or removal of an epidural or spinal catheter should be considered characteristic of the drug and the patient’s profile. After removal of the catheter following the dose of sodium bemiparin may be administered no earlier than 4 hours and only after completion of the surgical procedure.
The decision on the appointment of anticoagulant therapy in the context of epidural or spinal anesthesia is necessary to use extreme caution, including frequent monitoring to detect signs and symptoms of neurological disorders such as back pain, violation of sensitivity and motility (numbness and weakness of the lower limbs) and bowel dysfunction and bladder. Nursing staff should be trained to identify these signs and symptoms. Patients should be instructed as to the need for immediate information nurses or doctors in the event of these symptoms.
If you suspect the presence of an epidural or spinal hematoma clinical equipoise is urgently needed to establish a diagnosis of the adoption of therapeutic measures, up to the medullary decompression.

Effects on ability to drive vehicles and management mechanisms
The drug does not affect the ability to drive clinical equipoise vehicles and management mechanisms.

http://localgid.net/manufacturer/unigen-life-sciences/